While at an archaeology dig in Afghanistan, Rachel St. Claire, an evolutionary anthropologist, comes across a pendant with strange shifting symbols. Not long after, she receives an urgent call from her colleague, Dr. Grace McAllister, who insists that she come with her and her nephew, Trevor, a handsome polar geophysicist, to Antarctica to examine an unusual body that was found in an ice cave.
Before Rachel can respond, bandits sent by the ruthless Major General Braun storm the site. Just as they are about to seize Rachel, a helicopter appears with Trevor who has been sent to bring Rachel to Antarctica. Trevor soon falls in love with Rachel who, unfortunately, already has a fiance. Little does she know that a trusted friend is part of a group of bioterrorists who are engaged in genetic experiments in an abandoned World War II Nazi base under the Antarctic ice and who are after the pendant—and Rachel.